Multifunctional Receptor-Directed Drugs for Disorders of the Central Nervous System
Jerry J. Buccafusco
pages 4-13
Abstract | Full Text | Full-Text PDF (452 KB)

Multifunctional Drugs for Head Injury
Robert Vink, Alan J. Nimmo
pages 28-42
Abstract | Full Text | Full-Text PDF (186 KB)

Dual- and Triple-Acting Agents for Treating Core and Co-morbid Symptoms of Major Depression: Novel Concepts, New Drugs
Mark J. Millan
pages 53-77
Abstract | Full Text | Full-Text PDF (1319 KB)

Multifunctional Pharmacotherapy: What Can We Learn from Study of Selective Serotonin Reuptake Inhibitor Augmentation of Antipsychotics in Negative-Symptom Schizophrenia?
Henry Silver, Yael Chertkow, Orly Weinreb, Lena Danovich, Moussa Youdim
pages 86-93
Abstract | Full Text | Full-Text PDF (98 KB)

Therapeutic Potential of Erythropoietin and its Structural or Functional Variants in the Nervous System
Anna-Leena Sirén, Theresa Faßhauer, Claudia Bartels, Hannelore Ehrenreich
pages 108-127
Abstract | Full Text | Full-Text PDF (597 KB)

Dual-Target–Directed Drugs that Block Monoamine Oxidase B and Adenosine A2A Receptors for Parkinson's Disease
Jacobus P. Petzer, Neal Castagnoli, Michael A. Schwarzschild, Jiang-Fan Chen, Cornelis J. Van der Schyf
pages 141-151
Abstract | Full Text | Full-Text PDF (249 KB)

Multifunctional Neuroprotective Derivatives of Rasagiline as Anti-Alzheimer's Disease Drugs
Orly Weinreb, Silvia Mandel, Orit Bar-Am, Merav Yogev-Falach, Yael Avramovich-Tirosh, Tamar Amit, Moussa B.H. Youdim
pages 163-174
Abstract | Full Text | Full-Text PDF (388 KB)

Novel Anti-Alzheimer's Dimer Bis(7)-Cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets
Wenming Li, Marvin Mak, Hualiang Jiang, Qinwen Wang, Yuanping Pang, Kaixian Chen, Yifan Han
pages 187-201
Abstract | Full Text | Full-Text PDF (2253 KB)

Keynote Address—Unmet Clinical Research Needs for Persons with Pre-Manifest Huntington Disease
Charles Sabine
page 202
Full-Text PDF (40 KB)

Platform Presentation—Longitudinal Structural MRI Data from PREDICT-HD: Striatal and Cortical Changes in Pre-Clinical HD
E. Aylward, P. Nopoulos, H. Johnson, A. Juhl, V. Magnotta, R. Pierson, D. Langbehn, C. Ross, J. Paulsen, PREDICT-HD Investigators of the Huntington Study Group
pages 202-203
Abstract | Full-Text PDF (47 KB)

Keynote Address—GINA: Public Policy, Private Protection and Implications for Huntington Disease
Lewis Maltby
page 203
Full-Text PDF (41 KB)

Platform Presentation—Dimebon in Mild-to-Moderate Huntington's Disease: A Multicenter, Phase 2, Randomized, Placebo-Controlled Trial (DIMOND)
The Huntington Study Group
page 203
Abstract | Full-Text PDF (41 KB)

Poster 1: Survey of Clinical Trial Interest and Literacy in Huntington Support Groups: Northwest Pilot Project
L. Veatch Goodman, J. Giuliano, D. Lovecky
page 204
Abstract | Full-Text PDF (40 KB)

Poster 3: An Examination of Actual and Potential Discrimination of Individuals at Risk of Huntington's Disease: An Analysis of the RESPOND-HD Data from Australia (Site 144)
A. Goh, O. Yastrubetskaya, E. Chiu
pages 204-205
Abstract | Full-Text PDF (51 KB)

Poster 5: An Item Response Analysis of Depressive Symptomatology in Pre-Huntington Disease
A. Vaccarino, K. Anderson, B. Borowsky, K. Duff, K. Evans, J. Giuliano, M. Guttman, A. Ho, D. Langbehn, J. Paulsen, T. Sills, D. Van Kammen, FuRST-pHD and PREDICT-HD Investigators and Coordinators of the Huntington Study Group
page 205
Abstract | Full-Text PDF (43 KB)

Poster 7: Memory for Temporal Sequences for the Early Detection of Cognitive Changes in Preclinical Huntington's Disease
E. Pirogovsky, B. Bartlett, A. Callazo, J. Goldstein, G. Peavy, M. Jacobson, J. Corey-Bloom, P. Gilbert
page 206
Abstract | Full-Text PDF (41 KB)

Poster 9: Corticostriatal Abnormalities in HD: A Combined Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging Study
K.E. Weaver, T.L. Richards, O. Liang, E.H. Aylward
pages 206-207
Abstract | Full-Text PDF (50 KB)

Poster 11: Motor Symptom–Related Metabolic Network in Huntington's Disease
A. Feigin, C. Tang, K.L. Poston, Y. Ma, M. Guttman, J.S. Paulsen, V. Dhawan, D. Eidelberg
page 207
Abstract | Full-Text PDF (41 KB)

Poster 13: Early Diagnosis of Mitochondrial Dysfunction in Huntington's Disease In Vivo
K.E. Conley, S. Jubrias, C. Amara, E. Shankland, D.J. Marcinek, E. Aylward
page 208
Abstract | Full-Text PDF (40 KB)

Poster 15: Predicting Cognitive Decline: Another Method for Stratifying Samples?
K. Duff, L.J. Beglinger, J.C. Stout, J.S. Paulsen, PREDICT-HD Investigators of the Huntington Study Group
pages 208-209
Abstract | Full-Text PDF (49 KB)

Poster 17: Lifestyle Activity and the Age of Onset of Huntington Disease
K. Trembath, A. Churchyard, Z. Horton, L. Tippett, V. Hogg, R. Roxburgh, D. Velakoulis, V. Collins, M. Delatycki
page 209
Abstract | Full-Text PDF (41 KB)

Poster 19: Basal Ganglia Pathology in Preclinical and Early Symptomatic Huntington's Disease: Diffusion Tensor Imaging, Magnetic Resonance Spectroscopy, and Volumetric Measures—Which Imaging Modality Is More Sensitive?
P. Chua, P. Desmond, S. Christensen, C. Steward, D. Velakoulis, F. Judd, E. Chiu, J. Lloyd, B. Tress
page 210
Abstract | Full-Text PDF (41 KB)

Poster 21: Insurance Ownership and Genetic Risk
E. Oster, J. Bausch, A. Shinaman, E. Kayson, D. Oakes, I. Shoulson, K. Quaid, E.R. Dorsey, Huntington Study Group PHAROS Investigators
pages 210-211
Abstract | Full-Text PDF (50 KB)

Poster 23: Characterization of Frontal Lobe Behavioral Syndromes in Huntington's Disease (HD)
L. Oelke, L. Butterfield, C. Cimino, J. Sanchez-Ramos, M. McCall, M. Pugliese, L. Ling, B. Stell, J. Annis
page 211
Abstract | Full-Text PDF (41 KB)

Editorial Board
page A1
Full-Text PDF (10 KB)