Advertisement
Journal Home
Search for

Issue

Free This issue is open to the public.

Alert me when new journal issues are available via Request TOC Alert via emailor via Request RSS feed of current issue

previous issue next issue

Neurotherapeutics
Volume 7, Issue 1, Pages 1-148 (January 2010)
Search Within This Issue
Traumatic Brain Injury
Edited by Robert Vink, M. Ross Bullock

display abstract citation download email a colleague
Display:


Editorial Board
page i
Full-Text PDF (27 KB)


Contents
pages ii-iii
Full-Text PDF (41 KB)

Editorial


Traumatic Brain Injury: Therapeutic Challenges and New Directions
Robert Vink, M. Ross Bullock
pages 1-2
Full Text | Full-Text PDF (58 KB)

Review Articles


Cell Death Mechanisms and Modulation in Traumatic Brain Injury
Bogdan A. Stoica, Alan I. Faden
pages 3-12
Abstract | Full Text | Full-Text PDF (483 KB)


Mitochondrial Damage: A Target for New Therapeutic Horizons
Jean F. Soustiel, Sarit Larisch
pages 13-21
Abstract | Full Text | Full-Text PDF (739 KB)


Involvement of Pro- and Anti-Inflammatory Cytokines and Chemokines in the Pathophysiology of Traumatic Brain Injury
Jenna M. Ziebell, Maria Cristina Morganti-Kossmann
pages 22-30
Abstract | Full Text | Full-Text PDF (424 KB)


Calpain as a Therapeutic Target in Traumatic Brain Injury
Kathryn E. Saatman, Jennifer Creed, Ramesh Raghupathi
pages 31-42
Abstract | Full Text | Full-Text PDF (1393 KB)


The Evidence for Hypothermia as a Neuroprotectant in Traumatic Brain Injury
W. Dalton Dietrich, Helen M. Bramlett
pages 43-50
Abstract | Full Text | Full-Text PDF (204 KB)


Antioxidant Therapies for Traumatic Brain Injury
Edward D. Hall, Radhika A. Vaishnav, Ayman G. Mustafa
pages 51-61
Abstract | Full Text | Full-Text PDF (1081 KB)


Statins in Traumatic Brain Injury
Elissa F. Wible, Daniel T. Laskowitz
pages 62-73
Abstract | Full Text | Full-Text PDF (443 KB)


Substance P Antagonists as a Therapeutic Approach to Improving Outcome Following Traumatic Brain Injury
Robert Vink, Corinna van den Heuvel
pages 74-80
Abstract | Full Text | Full-Text PDF (478 KB)


Traumatic Brain Injury and Aging: Is a Combination of Progesterone and Vitamin D Hormone a Simple Solution to a Complex Problem?
Milos Cekic, Donald G. Stein
pages 81-90
Abstract | Full Text | Full-Text PDF (285 KB)


Use of Magnesium in Traumatic Brain Injury
Ananda P. Sen, Anil Gulati
pages 91-99
Abstract | Full Text | Full-Text PDF (245 KB)


Biomarkers for the Diagnosis, Prognosis, and Evaluation of Treatment Efficacy for Traumatic Brain Injury
Pramod K. Dash, Jing Zhao, Georgene Hergenroeder, Anthony N. Moore
pages 100-114
Abstract | Full Text | Full-Text PDF (414 KB)


Clinical Trials in Traumatic Brain Injury: Past Experience and Current Developments
Andrew I.R. Maas, Bob Roozenbeek, Geoffrey T. Manley
pages 115-126
Abstract | Full Text | Full-Text PDF (331 KB)


IMPACT Recommendations for Improving the Design and Analysis of Clinical Trials in Moderate to Severe Traumatic Brain Injury
Andrew I.R. Maas, Ewout W. Steyerberg, Anthony Marmarou, Gillian S. McHugh, Hester F. Lingsma, Isabella Butcher, Juan Lu, James Weir, Bob Roozenbeek, Gordon D. Murray
pages 127-134
Abstract | Full Text | Full-Text PDF (184 KB)

Huntington Study Group Abstracts


Poster viewing
page 135
Full-Text PDF (78 KB)


Introduction—Introduction and acknowledgments
Jang-Ho Cha, Richard Dubinsky
page 135
Full-Text PDF (79 KB)


Keynote address—Huntington's Advocacy: Why I Care
Judy Roberson
page 135
Abstract | Full-Text PDF (79 KB)


Platform presentation—Early Defect of Transforming Growth Factor β1 Formation in Huntington's Disease
G. Battaglia, M. Cannella, B. Riozzi, S. Orobello, M.L. Maat-Schieman, E. Aronica, C. Letizia Busceti, A. Ciarmiello, S. Alberti, J. Sassone, S. Sipione, V. Bruno, L. Frati, F. Nicoletti, F. Squitieri
pages 135-136
Abstract | Full-Text PDF (101 KB)


Platform presentation—Impairments in Precision Grip Control in Pre-symptomatic Huntington's Disease
A. Rao, A. Gordon, K. Marder
page 136
Abstract | Full-Text PDF (84 KB)


Break and poster viewing
page 136
Full-Text PDF (84 KB)


Keynote address—Working Toward Mesenchymal Stem Cell Therapy for HD
Jan Nolta
page 136
Abstract | Full-Text PDF (84 KB)


Platform presentation—Early vs Late Huntington's Disease: Is There a Difference in Psychiatric Symptom Severity?
K. Anderson, A. Gruber-Baldini, J. Medalie, S. Reich, P. Fishman, B. Robottom, W. Weiner, L. Shulman
page 136
Abstract | Full-Text PDF (84 KB)


Platform presentation—Late-breaking research—Multivariate Clinical Predictors of Huntington Disease (HD): Prospective Results from the PREDICT-HD Study
D. Langbehn, J. Paulsen, PREDICT-HD Investigators of the Huntington Study Group
page 137
Abstract | Full-Text PDF (76 KB)


Keynote address—FDA Regulation of Stem Cell Therapy
Celia Witten
page 137
Abstract | Full-Text PDF (76 KB)


Poster 1: Caregiver Quality of Life in Huntington's Disease
M. Cox, A. Feigin, B. Napolitano
page 138
Abstract | Full-Text PDF (83 KB)


Poster 2: Genetic Discrimination of Individuals at Risk of Huntington's Disease: Further Analysis of the RESPOND-HD Data From Australia (Site 144)
A. Goh, O. Yastrubetskaya, E. Chiu
page 138
Abstract | Full-Text PDF (83 KB)


Poster 3: Frequency of Epileptic Seizures in a Population of Juvenile Huntington's Disease Patients
L. Cloud, S. Helmers, R. Jones, S. Factor, C. Testa
pages 138-139
Abstract | Full-Text PDF (100 KB)


Poster 4: The Effect of Video Game-Based Exercise on Dynamic Balance and Mobility in Individuals with Huntington's Disease
D. Kegelmeyer, S. Kostyk, N. Fritz, A. Kloos
page 139
Abstract | Full-Text PDF (81 KB)


Poster 5: Usefulness of Two Brief Cognitive Screening Measures in Huntington's Disease
S. Lessig, J. Goldstein, J. Corey-Bloom
page 139
Abstract | Full-Text PDF (81 KB)


Poster 6: Cerebrospinal Fluid (CSF) Volume Is the Main Marker of Huntington Disease Progression Severity and Age-at-Onset Prediction
F. Squitieri, M. Cannella, M. Simonelli, T. Martino, C. Colonnese, A. Ciarmiello
pages 139-140
Abstract | Full-Text PDF (104 KB)


Poster 7: Early Defect of Transforming Growth Factor β1 Formation in Huntington's Disease
G. Battaglia, M. Cannella, B. Riozzi, S. Orobello, M.L. Maat-Schieman, E. Aronica, C. Letizia Busceti, A. Ciarmiello, S. Alberti, J. Sassone, S. Sipione, V. Bruno, L. Frati, F. Nicoletti, F. Squitieri
page 140
Abstract | Full-Text PDF (86 KB)


Poster 8: Reliability of the Problem Behaviours Assessment for HD (short version)–Data From the TRACK-HD Study
J. Callaghan, N. Arran, M.F. Boisse, A. Coleman, R. Dar Santos, E. Dumas, E. 't Hart, D. Justo, J. Read, M. Say, S. Van Den Bogaard, A. Durr, B. Leavitt, R. Roos, S. Tabrizi, C. Bourdet, E. van Duijn, D. Craufurd, TRACK-HD Investigators
page 140
Abstract | Full-Text PDF (87 KB)


Poster 9: The Short Version of the Problem Behaviours Assessment for HD (PBA-s): An Item Response Analysis Using Data from the TRACK-HD Study
K. Evans, A. Vaccarino, D. Craufurd, J. Callaghan, A. Durr, B. Leavitt, R. Roos, S. Tabrizi, TRACK-HD Investigators
page 140
Abstract | Full-Text PDF (86 KB)


Poster 10: Degree of Disability Is Predictive of Physical But Not Mental Health Quality of Life in Huntington's Disease
B. Robottom, K. Anderson, J. Medalie, A. Gruber-Baldini, P. Fishman, S. Reich, W. Weiner, L. Shulman
page 141
Abstract | Full-Text PDF (85 KB)


Poster 11: Striatal Volume Distinguishes Converters from Non-Converters: Findings from PREDICT-HD
E. Aylward, P. Nopoulos, C. Ross, R. Pierson, J. Mills, D. Langbehn, V. Magnotta, H. Johnson, J. Paulsen, PREDICT-HD Investigators and Coordinators of the Huntington Study Group
page 141
Abstract | Full-Text PDF (85 KB)


Poster 12: Self-Efficacy in Health Behaviors: Is There a Difference in Huntington vs Parkinson Disease?
A. Mitchell, K. Anderson, J. Medalie, A. Gruber-Baldini, B. Robottom, P. Fishman, S. Reich, W. Weiner, L. Shulman
pages 141-142
Abstract | Full-Text PDF (104 KB)


Poster 13: Huntington's Disease Disrupts Motor Control Mechanisms That Rely on Internal Models
J.C. Cortes, A. Dahmubed, K. Marder, J. Krakauer, P. Mazzoni
page 142
Abstract | Full-Text PDF (84 KB)


Poster 14: Evaluation of Novel Radiotracers Targeting Non-Dopaminergic Striatal Biomarkers in HD: 18F-FPEB and PET Imaging for Metabotropic Glutamate Receptor Type 5 (mGluR5) Expression in Healthy Subjects and Subjects with Huntington Disease (HD)
D. Russell, D. Jennings, G. Tamagnan, J. Seibyl, A. Koren, G. Zubal, K. Marek
page 142
Abstract | Full-Text PDF (84 KB)


Poster 15: A Successful Short- and Long-Term Recruiting Strategy for Huntington Clinical Trials: A Community Effort
L. Goodman, R. Carnes, J. Giuliano, L. Vetter
pages 142-143
Abstract | Full-Text PDF (95 KB)


Poster 16: Genetic Approach to Huntington's Disease Therapeutics
M. MacDonald, J. Min Lee, I. Sik Seong, E. Fossale, M.A. Anderson, V. Wheeler, J. Gusella
page 143
Abstract | Full-Text PDF (76 KB)


Poster 17: Metabolic Profiling in Non-Human Primate Model of Huntington's Disease Reveals Early Disruptions in Tryptophan Metabolism
J. Johnson, T. Yu, D. Jones, A. Chan
page 143
Abstract | Full-Text PDF (76 KB)


Poster 18: Lack of Awareness of Motor and Cognitive Phenoconversion in Huntington's Disease
K. Richardson, E. McCusker, C. Loy, J. Griffith, J. Mills, J.S. Paulsen, PREDICT-HD Investigators of the Huntington Study Group
page 144
Abstract | Full-Text PDF (83 KB)


Poster 19: Validation of the Modified Motor Score (mMS): A Subscale of the Unified Huntington's Disease Rating Scale (UHDRS) Motor Score
S. Waters, J. Tedroff, K. Kieburtz
page 144
Abstract | Full-Text PDF (83 KB)


Poster 20: Pridopidine (ACR16) in Huntington's Disease: An Update on the MermaiHD and HART Studies
J. Tedroff, P. Lindskov Krogh, A. Buusman, Å. Rembratt
pages 144-145
Abstract | Full-Text PDF (100 KB)


Poster 21: EURO-HDB—The First Large, Comprehensive European Study on the Burden of Huntington's Disease
J. Dorey, J. Tedroff, M. Lamure, M. Toumi
page 145
Abstract | Full-Text PDF (84 KB)


Poster 22: The Huntington Self-Assessment Instrument (HSAI): A Comprehensive and Specific Tool to Measure the Burden of Huntington's Disease
J. Tedroff, J. Dorey, M. Lamure, J.-M. Graf von der Schulenburg, M. Toumi
page 145
Abstract | Full-Text PDF (84 KB)


Poster 23: Pharmacology of the Dopaminergic Stabilizer Pridopidine (ACR16)
S. Waters, F. Pettersson, T. Dyhring, C. Sonesson, J. Tedroff, N. Waters, H. Pontén
pages 145-146
Abstract | Full-Text PDF (101 KB)


Poster 24: Worry and Experience of Genetic Discrimination in Persons at Risk for Huntington Disease
C. Erwin, J. Williams, A. Juhl, J. Paulsen, Investigators of the Huntington Study Group
page 146
Abstract | Full-Text PDF (84 KB)


Poster 25: Longitudinal Analysis of the UHDRS in Individuals At-Risk for Huntington's Disease by Gene Status: The Prospective Huntington's Disease Observational At-Risk Study (PHAROS)
Huntington Study Group PHAROS Investigators
page 146
Abstract | Full-Text PDF (84 KB)


Poster 26: Word Reading Compared to Demographics-Based Estimates of Premorbid IQ in Early Huntington Disease
W. Adams, J. Byars, J. O'Rourke, A. Flynn, J. Fiedorowicz, K. Duff, A. Leserman, P. Nopoulos, L. Beglinger
pages 146-147
Abstract | Full-Text PDF (102 KB)


Poster 27: Characterizing Psychomotor Declines in Prodromal Huntington Disease with the Trail Making Test
J. O'Rourke, L. Beglinger, J. Mills, M. Smith, J. Stout, S. Queller, S. Rao, J. Zimbelman, J. Paulsen
page 147
Abstract | Full-Text PDF (85 KB)


Poster 28: Delphi Process for the Development of Treatment Guidelines for Behavioral Symptoms and Chorea in Huntington's Disease
E. van Duijn, M. Groves, D. Craufurd, K. Anderson, M. Guttman, E. Wexler, S. Perlman, J.-M. Burgunder, A. Rosenblatt, D. van Kammen, J. Giuliano, L. Goodman
page 147
Abstract | Full-Text PDF (85 KB)


Poster 29: Multivariate Clinical Predictors of Huntington Disease (HD): Prospective Results from the PREDICT-HD Study
D. Langbehn, J. Paulsen, PREDICT-HD Investigators of the Huntington Study Group
page 147
Abstract | Full-Text PDF (85 KB)

display abstract citation download email a colleague
Display:
Advertisement